Drug interactions
Lomustine + Measles mumps and rubella vaccine
Severity: Contraindicated
Lomustine and Measles mumps and rubella vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine is a myelosuppressive cytotoxic agent, and live vaccine replication may be uncontrolled, risking disseminated vaccine-strain infection. The vaccine response may also be inadequate.
What this interaction means in plain words
Lomustine and Measles mumps and rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lomustine belongs to Oncology; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
Chemotherapy-induced immunosuppression permits unchecked replication of live attenuated virus.
What to do
Do not give live vaccines during chemotherapy; defer until immune recovery, typically at least 3 months after stopping.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
- Lomustine + Measles vaccine Contraindicated
Frequently asked questions
Can I take Lomustine with Measles mumps and rubella vaccine?
MediHelp rates the interaction as contraindicated. Lomustine and Measles mumps and rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomustine is a myelosuppressive cytotoxic agent, and live vaccine replication may be uncontrolled, risking disseminated vaccine-strain infection. The vaccine response may also be inadequate.
How serious is the interaction between Lomustine and Measles mumps and rubella vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during chemotherapy; defer until immune recovery, typically at least 3 months after stopping.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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