Drug interactions
Influenza virus vaccine quadrivalent intranasal + Lomustine
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Lomustine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which may replicate in patients immunosuppressed by lomustine and cause influenza illness. Protective response may also be impaired.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.
What to do
Do not use the live intranasal vaccine; give an inactivated injectable influenza vaccine instead, ideally timed away from the nadir of myelosuppression.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
- Lomustine + Measles vaccine Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Lomustine?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which may replicate in patients immunosuppressed by lomustine and cause influenza illness. Protective response may also be impaired.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Lomustine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine; give an inactivated injectable influenza vaccine instead, ideally timed away from the nadir of myelosuppression.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine. The full list is on the Lomustine page.
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