Drug interactions
Rubella vaccine + Temsirolimus
Severity: Contraindicated
Rubella vaccine and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rubella vaccine is live attenuated and may cause disseminated vaccine-strain infection in patients immunosuppressed by temsirolimus. The immune response may also be inadequate.
What this interaction means in plain words
Rubella vaccine and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of live attenuated virus replication.
What to do
Do not give during temsirolimus therapy. Vaccinate before treatment or after immune recovery, following local guidance.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Rubella vaccine with Temsirolimus?
MediHelp rates the interaction as contraindicated. Rubella vaccine and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rubella vaccine is live attenuated and may cause disseminated vaccine-strain infection in patients immunosuppressed by temsirolimus. The immune response may also be inadequate.
How serious is the interaction between Rubella vaccine and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give during temsirolimus therapy. Vaccinate before treatment or after immune recovery, following local guidance.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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