Drug interactions
Bcg vaccine live + Vedolizumab
Severity: Moderate
Bcg vaccine live and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG vaccine carries a risk of disseminated infection in patients on immunosuppressive therapy. Vedolizumab is gut-selective with less systemic effect, but caution still applies to live vaccines.
What this interaction means in plain words
Bcg vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Impaired immune control of a live attenuated organism, though vedolizumab's systemic effect is limited.
What to do
Avoid BCG vaccination during vedolizumab therapy unless the benefit clearly outweighs the risk. Where possible, give live vaccines at least several weeks before starting vedolizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Bcg vaccine live with Vedolizumab?
MediHelp rates the interaction as moderate. Bcg vaccine live and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG vaccine carries a risk of disseminated infection in patients on immunosuppressive therapy. Vedolizumab is gut-selective with less systemic effect, but caution still applies to live vaccines.
How serious is the interaction between Bcg vaccine live and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid BCG vaccination during vedolizumab therapy unless the benefit clearly outweighs the risk. Where possible, give live vaccines at least several weeks before starting vedolizumab.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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