Drug interactions
Etanercept + Vedolizumab
Severity: Major
Etanercept and Vedolizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab labeling advises against use with TNF blockers such as etanercept because of the potential for greater infection risk.
What this interaction means in plain words
Etanercept and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etanercept belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from gut-selective integrin blockade and systemic TNF-alpha inhibition.
What to do
Avoid combination use. Use one agent and monitor for infection if switching.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
- Upadacitinib + Vedolizumab Major
Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Vedolizumab?
MediHelp rates the interaction as major. Etanercept and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab labeling advises against use with TNF blockers such as etanercept because of the potential for greater infection risk.
How serious is the interaction between Etanercept and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination use. Use one agent and monitor for infection if switching.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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