Drug interactions
Bedaquiline + Capecitabine
Severity: Moderate
Bedaquiline and Capecitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and capecitabine has been rarely linked with cardiac effects including QT changes. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Bedaquiline and Capecitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Capecitabine belongs to Oncology.
Why it happens
Bedaquiline delays cardiac repolarization; capecitabine contribution is minor and uncertain.
What to do
Obtain a baseline ECG and monitor it during treatment, correcting electrolyte abnormalities. Avoid additional QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Capecitabine?
MediHelp rates the interaction as moderate. Bedaquiline and Capecitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval, and capecitabine has been rarely linked with cardiac effects including QT changes. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Bedaquiline and Capecitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, correcting electrolyte abnormalities. Avoid additional QT-prolonging agents.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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