Drug interactions
Disopyramide + Isoflurane
Severity: Major
Disopyramide and Isoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects. Isoflurane can add to QT prolongation and hypotension, raising the risk of arrhythmia and hemodynamic compromise.
What this interaction means in plain words
Disopyramide and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive negative inotropic and hypotensive effects.
What to do
Obtain an ECG and correct electrolytes before anesthesia. Monitor ECG and blood pressure continuously and have vasopressors and antiarrhythmic rescue available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Isoflurane?
MediHelp rates the interaction as major. Disopyramide and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and has negative inotropic and anticholinergic effects. Isoflurane can add to QT prolongation and hypotension, raising the risk of arrhythmia and hemodynamic compromise.
How serious is the interaction between Disopyramide and Isoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolytes before anesthesia. Monitor ECG and blood pressure continuously and have vasopressors and antiarrhythmic rescue available.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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