Drug interactions
Bedaquiline + Pazopanib
Severity: Major
Bedaquiline and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib and bedaquiline each can prolong the QTc interval. Together they raise the likelihood of clinically significant QT prolongation and arrhythmia.
What this interaction means in plain words
Bedaquiline and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and repeat it regularly during co-treatment, correcting electrolyte abnormalities. Discontinue the offending agent if QTc exceeds a safe threshold or arrhythmia symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Pazopanib?
MediHelp rates the interaction as major. Bedaquiline and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib and bedaquiline each can prolong the QTc interval. Together they raise the likelihood of clinically significant QT prolongation and arrhythmia.
How serious is the interaction between Bedaquiline and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it regularly during co-treatment, correcting electrolyte abnormalities. Discontinue the offending agent if QTc exceeds a safe threshold or arrhythmia symptoms occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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