Drug interactions
Belimumab + Upadacitinib
Severity: Moderate
Belimumab and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belimumab reduces B-cell survival, and combined with upadacitinib it may increase the risk of serious infection. Data on the combination are limited, and the effect is mainly extrapolated from additive immunosuppression.
What this interaction means in plain words
Belimumab and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belimumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from BLyS inhibition and JAK inhibition.
What to do
Avoid unless clearly needed. If used, monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Belimumab
- Belimumab + Measles mumps and rubella vaccine Major
- Abatacept + Belimumab Moderate
- Adalimumab + Belimumab Moderate
- Anakinra + Belimumab Moderate
- Anti-thymocyte + Belimumab Moderate
- Belimumab + Denosumab Moderate
Frequently asked questions
Can I take Belimumab with Upadacitinib?
MediHelp rates the interaction as moderate. Belimumab and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belimumab reduces B-cell survival, and combined with upadacitinib it may increase the risk of serious infection. Data on the combination are limited, and the effect is mainly extrapolated from additive immunosuppression.
How serious is the interaction between Belimumab and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly needed. If used, monitor for infection.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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