Drug interactions
Belladonna alkaloids + Trazodone
Severity: Minor
Belladonna alkaloids and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are potent antimuscarinic agents, while trazodone has only weak anticholinergic activity. Additive anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision are possible, especially in older patients, but are generally modest.
What this interaction means in plain words
Belladonna alkaloids and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects, with trazodone contributing weak anticholinergic activity.
What to do
Monitor for anticholinergic symptoms such as urinary retention, constipation and confusion, particularly in elderly patients. Reduce the belladonna dose if these effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Trazodone?
MediHelp rates the interaction as minor. Belladonna alkaloids and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belladonna alkaloids are potent antimuscarinic agents, while trazodone has only weak anticholinergic activity. Additive anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision are possible, especially in older patients, but are generally modest.
How serious is the interaction between Belladonna alkaloids and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as urinary retention, constipation and confusion, particularly in elderly patients. Reduce the belladonna dose if these effects emerge.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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