Drug interactions
Belladonna and opium + Melatonin
Severity: Moderate
Belladonna and opium and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component causes CNS and respiratory depression, which may be added to by the mild sedative effect of melatonin. Belladonna alkaloids can also cause drowsiness and confusion, especially in older adults.
What this interaction means in plain words
Belladonna and opium and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for excess sedation and respiratory depression, especially in elderly patients. Lower the opioid dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna and opium and Melatonin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
- Calcium / magnesium / potassium / sodium oxybates + Melatonin Moderate
Frequently asked questions
Can I take Belladonna and opium with Melatonin?
MediHelp rates the interaction as moderate. Belladonna and opium and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component causes CNS and respiratory depression, which may be added to by the mild sedative effect of melatonin. Belladonna alkaloids can also cause drowsiness and confusion, especially in older adults.
How serious is the interaction between Belladonna and opium and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, especially in elderly patients. Lower the opioid dose if needed.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Buprenorphine buccal. The full list is on the Melatonin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
