Drug interactions
Butabarbital + Melatonin
Severity: Moderate
Butabarbital and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate sedative-hypnotic, and melatonin adds a mild sedative effect. Together they may increase drowsiness and next-day impairment.
What this interaction means in plain words
Butabarbital and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation by the barbiturate and melatonin receptor-mediated sedation.
What to do
Avoid combining for sleep where possible; if used together, monitor for excessive sedation and advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butalbital + Melatonin Moderate
- Calcium / magnesium / potassium / sodium oxybates + Melatonin Moderate
Frequently asked questions
Can I take Butabarbital with Melatonin?
MediHelp rates the interaction as moderate. Butabarbital and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate sedative-hypnotic, and melatonin adds a mild sedative effect. Together they may increase drowsiness and next-day impairment.
How serious is the interaction between Butabarbital and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining for sleep where possible; if used together, monitor for excessive sedation and advise against driving or operating machinery.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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