Drug interactions
fluvoxamine + melatonin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Fluvoxamine markedly increases melatonin exposure, causing excessive sedation and psychomotor impairment.
Mechanism of action
Strong CYP1A2 inhibition by fluvoxamine reduces melatonin metabolism → sharply increased melatonin levels.
Clinical management
Avoid combination. If necessary, use the lowest melatonin dose with close monitoring for excessive sedation and cognitive/psychomotor impairment; advise against driving or hazardous tasks.
Drug reference
Frequently asked questions
Can I take fluvoxamine with melatonin?
The interaction is rated: Major. Fluvoxamine markedly increases melatonin exposure, causing excessive sedation and psychomotor impairment.
How serious is the interaction between fluvoxamine and melatonin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between fluvoxamine and melatonin managed?
Avoid combination. If necessary, use the lowest melatonin dose with close monitoring for excessive sedation and cognitive/psychomotor impairment; advise against driving or hazardous tasks.
Why do fluvoxamine and melatonin interact?
Strong CYP1A2 inhibition by fluvoxamine reduces melatonin metabolism → sharply increased melatonin levels.
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