Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Melatonin
Severity: Moderate
Calcium / magnesium / potassium / sodium oxybates and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause profound CNS and respiratory depression, and melatonin has mild sedative effects that may add to this. The clinical significance is likely modest but the oxybate risk is serious.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Counsel on increased sedation and monitor for respiratory depression, particularly at initiation. Avoid other sedatives alongside the oxybate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Melatonin?
MediHelp rates the interaction as moderate. Calcium / magnesium / potassium / sodium oxybates and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybates cause profound CNS and respiratory depression, and melatonin has mild sedative effects that may add to this. The clinical significance is likely modest but the oxybate risk is serious.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on increased sedation and monitor for respiratory depression, particularly at initiation. Avoid other sedatives alongside the oxybate.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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