Drug interactions
Belladonna and opium + Mirtazapine
Severity: Moderate
Belladonna and opium and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid sedation and respiratory depression to mirtazapine's sedative effect. Belladonna's anticholinergic activity may add confusion or constipation in susceptible patients.
What this interaction means in plain words
Belladonna and opium and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and sedating antidepressant effects, plus additive anticholinergic effects.
What to do
Start with the lowest opioid dose and monitor sedation and respiration. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Mirtazapine?
MediHelp rates the interaction as moderate. Belladonna and opium and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds opioid sedation and respiratory depression to mirtazapine's sedative effect. Belladonna's anticholinergic activity may add confusion or constipation in susceptible patients.
How serious is the interaction between Belladonna and opium and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest opioid dose and monitor sedation and respiration. Avoid alcohol and other sedatives.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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