Drug interactions
Belladonna and opium + Modafinil
Severity: Moderate
Belladonna and opium and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce CYP3A4 and reduce opioid exposure, and its alerting effect may mask sedation from the opiate. Anticholinergic and opioid effects of the suppository remain, and respiratory depression is not prevented by modafinil.
What this interaction means in plain words
Belladonna and opium and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 induction of opioid metabolism and opposing CNS effects.
What to do
Monitor pain control and respiratory status, and do not use alertness as a marker of opioid safety. Adjust the opioid dose to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Belladonna and opium with Modafinil?
MediHelp rates the interaction as moderate. Belladonna and opium and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may induce CYP3A4 and reduce opioid exposure, and its alerting effect may mask sedation from the opiate. Anticholinergic and opioid effects of the suppository remain, and respiratory depression is not prevented by modafinil.
How serious is the interaction between Belladonna and opium and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and respiratory status, and do not use alertness as a marker of opioid safety. Adjust the opioid dose to effect.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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