Drug interactions
Belladonna and opium + Oxycodone
Severity: Major
Belladonna and opium and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium contains an opioid (opium/morphine) so combined use with oxycodone gives additive opioid effects including sedation, respiratory depression and constipation. Belladonna alkaloids add anticholinergic effects such as urinary retention and ileus.
What this interaction means in plain words
Belladonna and opium and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive opioid receptor agonism and CNS/respiratory depression, with added anticholinergic effects.
What to do
Avoid concurrent use where possible; if unavoidable, use the lowest doses for the shortest time and monitor respiratory rate, sedation and bowel and bladder function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Oxycodone?
MediHelp rates the interaction as major. Belladonna and opium and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belladonna and opium contains an opioid (opium/morphine) so combined use with oxycodone gives additive opioid effects including sedation, respiratory depression and constipation. Belladonna alkaloids add anticholinergic effects such as urinary retention and ileus.
How serious is the interaction between Belladonna and opium and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, use the lowest doses for the shortest time and monitor respiratory rate, sedation and bowel and bladder function.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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