Drug interactions
Belladonna and opium + Sevoflurane
Severity: Moderate
Belladonna and opium and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component contributes opioid sedation and respiratory depression that add to sevoflurane, while belladonna alkaloids add anticholinergic effects such as tachycardia and confusion. Emergence may be delayed and ventilation depressed.
What this interaction means in plain words
Belladonna and opium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism, with added anticholinergic effects.
What to do
Reduce anesthetic and opioid doses as needed and monitor respiratory rate, oxygen saturation and heart rate. Extend postoperative observation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Belladonna and opium with Sevoflurane?
MediHelp rates the interaction as moderate. Belladonna and opium and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component contributes opioid sedation and respiratory depression that add to sevoflurane, while belladonna alkaloids add anticholinergic effects such as tachycardia and confusion. Emergence may be delayed and ventilation depressed.
How serious is the interaction between Belladonna and opium and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce anesthetic and opioid doses as needed and monitor respiratory rate, oxygen saturation and heart rate. Extend postoperative observation.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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