Drug interactions
Belladonna and opium + Tiotropium-olodaterol
Severity: Moderate
Belladonna and opium and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna provides antimuscarinic activity that adds to tiotropium, while opium contributes constipating and urinary-retaining effects. Together they may increase the risk of constipation, urinary retention, dry mouth and tachycardia. Older patients are at higher risk.
What this interaction means in plain words
Belladonna and opium and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with opioid-induced reduction in gut motility and urinary retention.
What to do
Monitor for urinary retention, constipation and anticholinergic symptoms, and use the lowest effective suppository dose. Avoid in patients with narrow-angle glaucoma or bladder outlet obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna and opium and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Belladonna and opium with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Belladonna and opium and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna provides antimuscarinic activity that adds to tiotropium, while opium contributes constipating and urinary-retaining effects. Together they may increase the risk of constipation, urinary retention, dry mouth and tachycardia. Older patients are at higher risk.
How serious is the interaction between Belladonna and opium and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and anticholinergic symptoms, and use the lowest effective suppository dose. Avoid in patients with narrow-angle glaucoma or bladder outlet obstruction.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
