Drug interactions
Arsenic trioxide + Tiotropium-olodaterol
Severity: Major
Arsenic trioxide and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide has a boxed warning for QT prolongation and torsades de pointes. Olodaterol may add to this risk through beta-adrenergic tachycardia and hypokalemia.
What this interaction means in plain words
Arsenic trioxide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Monitor ECG, potassium and magnesium closely, and keep electrolytes within normal range. Consider an alternative bronchodilator regimen if QT prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Arsenic trioxide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide has a boxed warning for QT prolongation and torsades de pointes. Olodaterol may add to this risk through beta-adrenergic tachycardia and hypokalemia.
How serious is the interaction between Arsenic trioxide and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium closely, and keep electrolytes within normal range. Consider an alternative bronchodilator regimen if QT prolongation develops.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Carvedilol. The full list is on the Tiotropium-olodaterol page.
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