Drug interactions
Disopyramide + Tiotropium-olodaterol
Severity: Major
Disopyramide and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and can cause torsades de pointes, and beta2-agonists may add to cardiac stimulation and lower potassium. Disopyramide also has strong anticholinergic effects that add to tiotropium. The combination raises the risk of ventricular arrhythmias.
What this interaction means in plain words
Disopyramide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-mediated hypokalemia, plus additive antimuscarinic effects.
What to do
Monitor ECG and potassium and magnesium closely, and avoid exceeding the labeled olodaterol dose. Watch for anticholinergic effects such as urinary retention.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Disopyramide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and can cause torsades de pointes, and beta2-agonists may add to cardiac stimulation and lower potassium. Disopyramide also has strong anticholinergic effects that add to tiotropium. The combination raises the risk of ventricular arrhythmias.
How serious is the interaction between Disopyramide and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium and magnesium closely, and avoid exceeding the labeled olodaterol dose. Watch for anticholinergic effects such as urinary retention.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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