Drug interactions
Amisulpride + Tiotropium-olodaterol
Severity: Major
Amisulpride and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride prolongs the QTc interval in a dose-dependent manner, and olodaterol as a long-acting beta-agonist may add to cardiac repolarisation effects and hypokalemia. Together they may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Amisulpride and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QTc prolongation, with beta-2 agonist-induced hypokalemia and sympathetic stimulation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during treatment and choose alternatives if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Amisulpride and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride prolongs the QTc interval in a dose-dependent manner, and olodaterol as a long-acting beta-agonist may add to cardiac repolarisation effects and hypokalemia. Together they may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Amisulpride and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG during treatment and choose alternatives if QTc becomes markedly prolonged.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Arformoterol, Arsenic trioxide, Carvedilol. The full list is on the Tiotropium-olodaterol page.
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