Drug interactions
Chloroquine + Tiotropium-olodaterol
Severity: Major
Chloroquine and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine can prolong the QT interval and cause arrhythmias, and olodaterol may add cardiac stimulation and hypokalemia. The combination increases the risk of serious ventricular arrhythmia, especially with other risk factors.
What this interaction means in plain words
Chloroquine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-2 agonist-related sympathetic stimulation and potassium lowering.
What to do
Check a baseline ECG, potassium and magnesium, and correct abnormalities before starting. Monitor the ECG and consider alternatives if QTc lengthens markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Chloroquine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloroquine can prolong the QT interval and cause arrhythmias, and olodaterol may add cardiac stimulation and hypokalemia. The combination increases the risk of serious ventricular arrhythmia, especially with other risk factors.
How serious is the interaction between Chloroquine and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG, potassium and magnesium, and correct abnormalities before starting. Monitor the ECG and consider alternatives if QTc lengthens markedly.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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