Drug interactions
Belladonna and opium + Trazodone
Severity: Moderate
Belladonna and opium and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium contributes opioid-mediated CNS and respiratory depression, which adds to the sedating effect of trazodone. Belladonna adds anticholinergic effects and may worsen drowsiness and confusion. Serotonergic effects are also possible with opioids.
What this interaction means in plain words
Belladonna and opium and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and sedative antidepressant effects, with added anticholinergic burden.
What to do
Use the lowest effective doses and monitor for excessive sedation, respiratory depression and confusion, especially in older adults. Warn patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Trazodone?
MediHelp rates the interaction as moderate. Belladonna and opium and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium contributes opioid-mediated CNS and respiratory depression, which adds to the sedating effect of trazodone. Belladonna adds anticholinergic effects and may worsen drowsiness and confusion. Serotonergic effects are also possible with opioids.
How serious is the interaction between Belladonna and opium and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation, respiratory depression and confusion, especially in older adults. Warn patients to avoid alcohol and other sedatives.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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