Drug interactions
Belzutifan + Brexpiprazole
Severity: Moderate
Belzutifan and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower brexpiprazole concentrations. Psychiatric symptom control could be reduced.
What this interaction means in plain words
Belzutifan and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Brexpiprazole belongs to Central Nervous System.
Why it happens
Belzutifan induces CYP3A4, increasing brexpiprazole clearance.
What to do
Monitor for loss of efficacy and consider increasing the brexpiprazole dose if needed. Reduce the dose again if belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Brexpiprazole?
MediHelp rates the interaction as moderate. Belzutifan and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower brexpiprazole concentrations. Psychiatric symptom control could be reduced.
How serious is the interaction between Belzutifan and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider increasing the brexpiprazole dose if needed. Reduce the dose again if belzutifan is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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