Drug interactions
Belzutifan + Clarithromycin
Severity: Moderate
Belzutifan and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a CYP3A4 inducer and may lower clarithromycin concentrations, potentially reducing antibacterial effect. Belzutifan levels may also be affected by clarithromycin through CYP3A4 inhibition of its metabolism.
What this interaction means in plain words
Belzutifan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Clarithromycin belongs to Anti Bacterial.
Why it happens
Belzutifan induces CYP3A4, accelerating clarithromycin metabolism.
What to do
Monitor for reduced clarithromycin efficacy and consider an alternative antibiotic not dependent on CYP3A4 if infection response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Clarithromycin?
MediHelp rates the interaction as moderate. Belzutifan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is a CYP3A4 inducer and may lower clarithromycin concentrations, potentially reducing antibacterial effect. Belzutifan levels may also be affected by clarithromycin through CYP3A4 inhibition of its metabolism.
How serious is the interaction between Belzutifan and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clarithromycin efficacy and consider an alternative antibiotic not dependent on CYP3A4 if infection response is inadequate.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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