Drug interactions
Belzutifan + Crizotinib
Severity: Moderate
Belzutifan and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower crizotinib concentrations, potentially reducing antitumor efficacy. The size of the effect on crizotinib has not been well characterized.
What this interaction means in plain words
Belzutifan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Crizotinib belongs to Oncology.
Why it happens
Belzutifan induces CYP3A4, increasing crizotinib metabolism.
What to do
Monitor for loss of crizotinib response and consider alternatives if the combination is needed. Do not adjust the dose without specialist input.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Crizotinib?
MediHelp rates the interaction as moderate. Belzutifan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower crizotinib concentrations, potentially reducing antitumor efficacy. The size of the effect on crizotinib has not been well characterized.
How serious is the interaction between Belzutifan and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of crizotinib response and consider alternatives if the combination is needed. Do not adjust the dose without specialist input.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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