Drug interactions
Belzutifan + Dasatinib
Severity: Moderate
Belzutifan and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower dasatinib exposure. Reduced dasatinib levels could compromise control of leukemia.
What this interaction means in plain words
Belzutifan and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Dasatinib belongs to Oncology.
Why it happens
Belzutifan induction of CYP3A4 increases dasatinib metabolism.
What to do
Monitor hematologic and molecular response and consider dasatinib dose adjustment if response is lost. Use an alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Dasatinib?
MediHelp rates the interaction as moderate. Belzutifan and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower dasatinib exposure. Reduced dasatinib levels could compromise control of leukemia.
How serious is the interaction between Belzutifan and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic and molecular response and consider dasatinib dose adjustment if response is lost. Use an alternative where possible.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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