Drug interactions
Belzutifan + Eplerenone
Severity: Moderate
Belzutifan and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan can induce CYP3A4, and eplerenone is a CYP3A4 substrate. Exposure to eplerenone may fall, reducing its blood pressure or cardiac benefit.
What this interaction means in plain words
Belzutifan and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Eplerenone belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by belzutifan, increasing eplerenone metabolism.
What to do
Monitor blood pressure and clinical response to eplerenone, and increase its dose as needed. Re-evaluate the dose if belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Eplerenone?
MediHelp rates the interaction as moderate. Belzutifan and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan can induce CYP3A4, and eplerenone is a CYP3A4 substrate. Exposure to eplerenone may fall, reducing its blood pressure or cardiac benefit.
How serious is the interaction between Belzutifan and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response to eplerenone, and increase its dose as needed. Re-evaluate the dose if belzutifan is stopped.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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