Drug interactions
Belzutifan + Fluconazole
Severity: Moderate
Belzutifan and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP3A4, pathways involved in belzutifan metabolism, which may increase belzutifan exposure. This may worsen anemia and hypoxia, known toxicities of belzutifan.
What this interaction means in plain words
Belzutifan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C19 and CYP3A4 reduces belzutifan metabolism.
What to do
Monitor hemoglobin and oxygen saturation closely, and reduce the belzutifan dose as directed in labeling if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Fluconazole?
MediHelp rates the interaction as moderate. Belzutifan and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C19 and CYP3A4, pathways involved in belzutifan metabolism, which may increase belzutifan exposure. This may worsen anemia and hypoxia, known toxicities of belzutifan.
How serious is the interaction between Belzutifan and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation closely, and reduce the belzutifan dose as directed in labeling if adverse effects arise.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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