Drug interactions
Belzutifan + Fluvoxamine
Severity: Moderate
Belzutifan and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is cleared partly via CYP2C19, which fluvoxamine strongly inhibits. Raised belzutifan exposure may worsen anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated metabolism of belzutifan, raising plasma concentrations.
What to do
Monitor hemoglobin and oxygen saturation closely. Reduce the belzutifan dose if adverse effects arise or consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Fluvoxamine?
MediHelp rates the interaction as moderate. Belzutifan and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is cleared partly via CYP2C19, which fluvoxamine strongly inhibits. Raised belzutifan exposure may worsen anemia and hypoxia.
How serious is the interaction between Belzutifan and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation closely. Reduce the belzutifan dose if adverse effects arise or consider an alternative antidepressant.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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