Drug interactions
Belzutifan + Itraconazole
Severity: Moderate
Belzutifan and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4, which may lower itraconazole concentrations and compromise antifungal efficacy. Belzutifan may also reduce the effectiveness of other CYP3A4 substrates.
What this interaction means in plain words
Belzutifan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Belzutifan induces CYP3A4, increasing itraconazole metabolism.
What to do
Monitor itraconazole serum concentrations and clinical response, and adjust the itraconazole dose or choose an alternative antifungal if levels are inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belzutifan and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Itraconazole?
MediHelp rates the interaction as moderate. Belzutifan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4, which may lower itraconazole concentrations and compromise antifungal efficacy. Belzutifan may also reduce the effectiveness of other CYP3A4 substrates.
How serious is the interaction between Belzutifan and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor itraconazole serum concentrations and clinical response, and adjust the itraconazole dose or choose an alternative antifungal if levels are inadequate.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
