Drug interactions
Belzutifan + Omeprazole
Severity: Moderate
Belzutifan and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19, one of the pathways metabolizing belzutifan. Higher belzutifan levels may worsen anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2C19-mediated belzutifan metabolism raises its exposure.
What to do
Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if adverse effects occur. Consider an alternative acid suppressant such as an H2 blocker.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Omeprazole?
MediHelp rates the interaction as moderate. Belzutifan and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole inhibits CYP2C19, one of the pathways metabolizing belzutifan. Higher belzutifan levels may worsen anemia and hypoxia.
How serious is the interaction between Belzutifan and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if adverse effects occur. Consider an alternative acid suppressant such as an H2 blocker.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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