Drug interactions
Benazepril + Carbidopa
Severity: Moderate
Benazepril and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can increase the risk of orthostatic hypotension. With benazepril, additive blood pressure lowering may require dose adjustment of the antihypertensive.
What this interaction means in plain words
Benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Increased central and peripheral dopamine availability from levodopa/carbidopa produces vasodilation that adds to ACE inhibitor effects.
What to do
Monitor blood pressure and orthostatic symptoms when starting levodopa/carbidopa, and reduce benazepril if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Benazepril with Carbidopa?
MediHelp rates the interaction as moderate. Benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, can increase the risk of orthostatic hypotension. With benazepril, additive blood pressure lowering may require dose adjustment of the antihypertensive.
How serious is the interaction between Benazepril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting levodopa/carbidopa, and reduce benazepril if hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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