Drug interactions
Benazepril + Chlorothiazide
Severity: Moderate
Benazepril and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide adds to the blood-pressure-lowering effect of benazepril, and volume depletion can cause first-dose hypotension and decline in renal function. Electrolyte disturbances may also occur.
What this interaction means in plain words
Benazepril and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from diuretic-induced volume depletion and renin-angiotensin system blockade.
What to do
Start benazepril at a low dose in diuretic-treated patients, or temporarily reduce the diuretic. Monitor blood pressure, creatinine and electrolytes after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Benazepril with Chlorothiazide?
MediHelp rates the interaction as moderate. Benazepril and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide adds to the blood-pressure-lowering effect of benazepril, and volume depletion can cause first-dose hypotension and decline in renal function. Electrolyte disturbances may also occur.
How serious is the interaction between Benazepril and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start benazepril at a low dose in diuretic-treated patients, or temporarily reduce the diuretic. Monitor blood pressure, creatinine and electrolytes after initiation.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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