Drug interactions
Benazepril + Diclofenac
Severity: Major
Benazepril and Diclofenac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce the antihypertensive effect of benazepril and may worsen renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia can also occur.
What this interaction means in plain words
Benazepril and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis by the NSAID counteracts ACE inhibitor vasodilation and reduces glomerular filtration.
What to do
Use an alternative analgesic where possible. If coadministered, maintain hydration and monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Diclofenac?
MediHelp rates the interaction as major. Benazepril and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac can reduce the antihypertensive effect of benazepril and may worsen renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia can also occur.
How serious is the interaction between Benazepril and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic where possible. If coadministered, maintain hydration and monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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