Drug interactions
Benazepril + Methohexital
Severity: Moderate
Benazepril and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturate anesthetics can cause vasodilation and myocardial depression, and patients taking ACE inhibitors may have exaggerated hypotension during induction. Blood pressure should be watched closely in the perioperative period.
What this interaction means in plain words
Benazepril and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Methohexital belongs to Central Nervous System.
Why it happens
Additive hypotension from barbiturate-induced vasodilation and reduced cardiac output with blockade of angiotensin II-mediated vascular tone.
What to do
Ensure adequate volume status and monitor blood pressure continuously during induction. Consider holding benazepril on the morning of surgery per local anesthesia protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Methohexital
Frequently asked questions
Can I take Benazepril with Methohexital?
MediHelp rates the interaction as moderate. Benazepril and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturate anesthetics can cause vasodilation and myocardial depression, and patients taking ACE inhibitors may have exaggerated hypotension during induction. Blood pressure should be watched closely in the perioperative period.
How serious is the interaction between Benazepril and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate volume status and monitor blood pressure continuously during induction. Consider holding benazepril on the morning of surgery per local anesthesia protocols.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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