Drug interactions
Benazepril + Obinutuzumab
Severity: Moderate
Benazepril and Obinutuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab infusions can cause hypotension as part of infusion-related reactions. Patients on antihypertensives such as benazepril may therefore experience more pronounced drops in blood pressure around the infusion.
What this interaction means in plain words
Benazepril and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Obinutuzumab belongs to Oncology.
Why it happens
Additive hypotensive effect of infusion-related reactions and ACE inhibitor-mediated blood pressure lowering.
What to do
Consider withholding benazepril for the 12 hours before the infusion and until 1 hour after the infusion, if clinically acceptable, and monitor blood pressure during infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Benazepril with Obinutuzumab?
MediHelp rates the interaction as moderate. Benazepril and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obinutuzumab infusions can cause hypotension as part of infusion-related reactions. Patients on antihypertensives such as benazepril may therefore experience more pronounced drops in blood pressure around the infusion.
How serious is the interaction between Benazepril and Obinutuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding benazepril for the 12 hours before the infusion and until 1 hour after the infusion, if clinically acceptable, and monitor blood pressure during infusion.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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