Drug interactions
Benazepril + Phentolamine
Severity: Moderate
Benazepril and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is a potent alpha-adrenergic blocker that causes vasodilation and hypotension. With benazepril, an exaggerated drop in blood pressure may occur, especially after the first dose.
What this interaction means in plain words
Benazepril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure closely during phentolamine administration, with the patient supine initially. Be ready to adjust doses or give fluids if significant hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Benazepril with Phentolamine?
MediHelp rates the interaction as moderate. Benazepril and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is a potent alpha-adrenergic blocker that causes vasodilation and hypotension. With benazepril, an exaggerated drop in blood pressure may occur, especially after the first dose.
How serious is the interaction between Benazepril and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during phentolamine administration, with the patient supine initially. Be ready to adjust doses or give fluids if significant hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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