Drug interactions
Benazepril + Quetiapine
Severity: Moderate
Benazepril and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which may add to the effect of benazepril. The risk is greatest during initiation and dose escalation.
What this interaction means in plain words
Benazepril and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism and ACE inhibition.
What to do
Monitor orthostatic blood pressure during quetiapine titration and counsel patients on slow position changes. Adjust the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Benazepril with Quetiapine?
MediHelp rates the interaction as moderate. Benazepril and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which may add to the effect of benazepril. The risk is greatest during initiation and dose escalation.
How serious is the interaction between Benazepril and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure during quetiapine titration and counsel patients on slow position changes. Adjust the antihypertensive dose if symptomatic.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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