Drug interactions
Benazepril + Riociguat
Severity: Moderate
Benazepril and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is a vasodilator that lowers blood pressure, and combining it with benazepril may cause symptomatic hypotension. The risk is greatest at initiation and during dose titration.
What this interaction means in plain words
Benazepril and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Stimulation of soluble guanylate cyclase causes vasodilation that adds to the hemodynamic effect of ACE inhibition.
What to do
Check blood pressure and symptoms of hypotension when starting or increasing riociguat, and consider a lower starting dose or reduction of the antihypertensive if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Benazepril with Riociguat?
MediHelp rates the interaction as moderate. Benazepril and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat is a vasodilator that lowers blood pressure, and combining it with benazepril may cause symptomatic hypotension. The risk is greatest at initiation and during dose titration.
How serious is the interaction between Benazepril and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and symptoms of hypotension when starting or increasing riociguat, and consider a lower starting dose or reduction of the antihypertensive if needed.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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