Drug interactions
Benazepril + Saxagliptin-metformin
Severity: Moderate
Benazepril and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as saxagliptin have been associated with a higher risk of angioedema when combined with ACE inhibitors. ACE inhibitors may also enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Both effects are uncommon.
What this interaction means in plain words
Benazepril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Both drug classes reduce degradation of substance P and bradykinin, which may add to angioedema risk; ACE inhibitors may improve insulin sensitivity.
What to do
Counsel patients to report lip, tongue or facial swelling immediately and stop the drugs if it occurs. Monitor glucose for hypoglycemia when starting the ACE inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Benazepril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as saxagliptin have been associated with a higher risk of angioedema when combined with ACE inhibitors. ACE inhibitors may also enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Both effects are uncommon.
How serious is the interaction between Benazepril and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report lip, tongue or facial swelling immediately and stop the drugs if it occurs. Monitor glucose for hypoglycemia when starting the ACE inhibitor.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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