Drug interactions
Benazepril + Tolazamide
Severity: Minor
Benazepril and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas. This can occasionally lead to hypoglycemia, especially after starting the ACE inhibitor.
What this interaction means in plain words
Benazepril and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Improved insulin sensitivity with ACE inhibition adds to the insulin secretagogue effect of the sulfonylurea.
What to do
Monitor blood glucose when benazepril is started or adjusted, and teach patients the symptoms of hypoglycemia. Reduce the sulfonylurea dose if low glucose readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Benazepril with Tolazamide?
MediHelp rates the interaction as minor. Benazepril and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas. This can occasionally lead to hypoglycemia, especially after starting the ACE inhibitor.
How serious is the interaction between Benazepril and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when benazepril is started or adjusted, and teach patients the symptoms of hypoglycemia. Reduce the sulfonylurea dose if low glucose readings occur.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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