Drug interactions
Benazepril + Tolbutamide
Severity: Minor
Benazepril and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas. Hypoglycemia is uncommon but may occur, particularly early in combined therapy.
What this interaction means in plain words
Benazepril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Improved insulin sensitivity with ACE inhibition adds to the insulin secretagogue effect of the sulfonylurea.
What to do
Monitor blood glucose when benazepril is started or adjusted, and counsel on hypoglycemia symptoms. Reduce the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Benazepril with Tolbutamide?
MediHelp rates the interaction as minor. Benazepril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas. Hypoglycemia is uncommon but may occur, particularly early in combined therapy.
How serious is the interaction between Benazepril and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when benazepril is started or adjusted, and counsel on hypoglycemia symptoms. Reduce the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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