Drug interactions
Benazepril + Tolfenamic acid
Severity: Moderate
Benazepril and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of ACE inhibitors. In patients with volume depletion, older age or renal impairment, the combination can also reduce kidney function.
What this interaction means in plain words
Benazepril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces vasodilation and renal perfusion that support the action of ACE inhibitors.
What to do
Use the shortest NSAID course possible, monitor blood pressure, and check serum creatinine and potassium in at-risk patients; ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Benazepril with Tolfenamic acid?
MediHelp rates the interaction as moderate. Benazepril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of ACE inhibitors. In patients with volume depletion, older age or renal impairment, the combination can also reduce kidney function.
How serious is the interaction between Benazepril and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest NSAID course possible, monitor blood pressure, and check serum creatinine and potassium in at-risk patients; ensure adequate hydration.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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