Drug interactions
Benazepril + Treprostinil
Severity: Moderate
Benazepril and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and can cause systemic hypotension. Combined with benazepril, hypotension may be more pronounced.
What this interaction means in plain words
Benazepril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory effects of prostacyclin analogue and ACE inhibition.
What to do
Monitor blood pressure during treprostinil initiation and dose titration, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Benazepril with Treprostinil?
MediHelp rates the interaction as moderate. Benazepril and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator and can cause systemic hypotension. Combined with benazepril, hypotension may be more pronounced.
How serious is the interaction between Benazepril and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during treprostinil initiation and dose titration, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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