Drug interactions
Benazepril + Vardenafil
Severity: Minor
Benazepril and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil's vasodilating effect can add to the blood pressure lowering of benazepril. Most patients tolerate it, but dizziness or hypotension may occur.
What this interaction means in plain words
Benazepril and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation and hypotension from PDE5 inhibition and ACE inhibition.
What to do
Monitor blood pressure when vardenafil is started and counsel on orthostatic symptoms. Use the lowest effective vardenafil dose in patients with low blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Vardenafil?
MediHelp rates the interaction as minor. Benazepril and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vardenafil's vasodilating effect can add to the blood pressure lowering of benazepril. Most patients tolerate it, but dizziness or hypotension may occur.
How serious is the interaction between Benazepril and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when vardenafil is started and counsel on orthostatic symptoms. Use the lowest effective vardenafil dose in patients with low blood pressure.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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