Drug interactions
Benazepril + Voclosporin
Severity: Major
Benazepril and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, nephrotoxicity and reduced glomerular filtration, and ACE inhibitors can add to potassium retention and renal hemodynamic effects. Together they may increase the risk of hyperkalemia and acute kidney injury.
What this interaction means in plain words
Benazepril and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibition causes afferent vasoconstriction and reduced potassium excretion, which is compounded by ACE inhibitor aldosterone suppression and efferent dilation.
What to do
Monitor serum potassium and eGFR frequently, particularly after initiation or dose changes of either drug. Reduce or interrupt voclosporin or adjust benazepril if hyperkalemia or a significant eGFR decline occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Benazepril with Voclosporin?
MediHelp rates the interaction as major. Benazepril and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, nephrotoxicity and reduced glomerular filtration, and ACE inhibitors can add to potassium retention and renal hemodynamic effects. Together they may increase the risk of hyperkalemia and acute kidney injury.
How serious is the interaction between Benazepril and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR frequently, particularly after initiation or dose changes of either drug. Reduce or interrupt voclosporin or adjust benazepril if hyperkalemia or a significant eGFR decline occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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