Drug interactions
Bendamustine + Epcoritamab
Severity: Moderate
Bendamustine and Epcoritamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that may temporarily suppress CYP enzymes, potentially increasing exposure to CYP1A2 substrates such as bendamustine. Both also cause cytopenias and infection risk.
What this interaction means in plain words
Bendamustine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Epcoritamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP1A2 activity, with additive myelosuppression.
What to do
Monitor blood counts and for bendamustine toxicity especially after the first epcoritamab doses and during cytokine release syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bendamustine
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
- Cyclosporin + Epcoritamab Moderate
Frequently asked questions
Can I take Bendamustine with Epcoritamab?
MediHelp rates the interaction as moderate. Bendamustine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that may temporarily suppress CYP enzymes, potentially increasing exposure to CYP1A2 substrates such as bendamustine. Both also cause cytopenias and infection risk.
How serious is the interaction between Bendamustine and Epcoritamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for bendamustine toxicity especially after the first epcoritamab doses and during cytokine release syndrome.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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