Drug interactions
Clomipramine + Epcoritamab
Severity: Moderate
Clomipramine and Epcoritamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab releases cytokines that can transiently suppress CYP enzyme activity, potentially increasing clomipramine exposure. The effect is most relevant around the first doses and during cytokine release syndrome.
What this interaction means in plain words
Clomipramine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Epcoritamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP enzymes increases substrate concentrations.
What to do
Monitor for clomipramine toxicity, including sedation, anticholinergic effects and palpitations, during early epcoritamab treatment and any CRS. Adjust the clomipramine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
- Cyclosporin + Epcoritamab Moderate
Frequently asked questions
Can I take Clomipramine with Epcoritamab?
MediHelp rates the interaction as moderate. Clomipramine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab releases cytokines that can transiently suppress CYP enzyme activity, potentially increasing clomipramine exposure. The effect is most relevant around the first doses and during cytokine release syndrome.
How serious is the interaction between Clomipramine and Epcoritamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clomipramine toxicity, including sedation, anticholinergic effects and palpitations, during early epcoritamab treatment and any CRS. Adjust the clomipramine dose if needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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